Unlocking the Potential: Psychedelics and the Growth of New Brain Cells

In recent years, neurogenesis, the growth of new brain cells, has emerged as a captivating topic within the realm of psychedelics. At Confluence Retreats, we are dedicated to exploring whether psychedelics, such as psilocybin-containing mushrooms, could contribute to the development and regeneration of human brain cells. Here's what we currently understand about neurogenesis and the potential connection to psychedelics.

Understanding Neurogenesis

Neurogenesis involves the generation of new brain cells, known as neurons. Unlike most other cells in the body, neurons cannot divide on their own, and the number of neurons in your brain remains relatively stable throughout your life. However, certain brain regions can produce new neurons in adulthood.

This process is facilitated by neural stem cells, specialized cells that remain dormant in the brain until they receive signals to transform into neurons. Neurogenesis primarily occurs in specific brain areas and is associated with improved learning, the formation of robust memories, and even the alleviation of depression.

Recent evidence suggests that psychedelic compounds like psilocybin may enhance natural neurogenesis in the brain. How could this potentially impact our daily lives, and could it be incorporated into psychedelic ceremonies like those offered at Confluence Retreats?

Neurogenesis and Its Role in Adults

In adults, neurogenesis is associated with three main cognitive areas: learning, memory, and mitigating depression. The prevailing theory suggests that neurogenesis in the hippocampus, a specific brain region, contributes to memory development and may influence our ability to acquire new behaviors.

However, the exact importance of neurogenesis in learning and memory remains the subject of ongoing research. In addition to the growth of neurons, the formation of new connections between neurons, known as neuroplasticity, is considered vital in the context of learning and memory.

There is a more substantial connection between neurogenesis and depression. Individuals experiencing depression may exhibit a reduced number of cells in their hippocampus. Some of the commonly prescribed antidepressants have been shown to stimulate neurogenesis, potentially aiding in the growth of new neurons. Therefore, neurogenesis appears to be a crucial factor for individuals dealing with depression or anxiety, as well as being involved in memory and learning processes.

Can Psychedelics Enhance Neurogenesis?

While research in this field is still in its early stages, there is some evidence suggesting that various psychedelics could promote neurogenesis.

Evidence with LSD and DMT

Synthetic psychedelics like LSD and DMT have been shown to facilitate neuron growth in the human brain. However, it's essential to note that the research indicates these substances primarily enhance the growth of mature neurons rather than generating entirely new ones. Studies involving rat neurons demonstrated that the addition of LSD or DMT in a lab setting promoted the growth of neurons with increased branching connections. This potential capability could potentially restore damaged brain regions affected by conditions like depression. However, further human studies are required to confirm this effect conclusively.

Evidence with Psilocybin

Psilocybin, the psychedelic found in the mushrooms used at the Confluence Retreats, has also exhibited potential involvement in neurogenesis. A study led by Briony Catlow at Johns Hopkins University in 2013 administered psilocybin to mice and subsequently examined their brains for signs of neurogenesis. The results indicated that standard doses of psilocybin slightly increased the number of new cells growing in the hippocampus of the mice.

While these findings are preliminary and their translation to humans is uncertain, they suggest that psilocybin may have the capacity to stimulate the growth of new neurons in the hippocampus.

Evidence with Ayahuasca

Certain components of ayahuasca, a traditional South American psychedelic brew, have demonstrated the ability to boost neuron growth in laboratory settings. A study led by Jose Morales-Garcia in Madrid in 2017 utilized neural stem cells derived from the brains of adult mice. These stem cells, grown in a lab environment, naturally formed clusters called "neurospheres," which subsequently developed into neurons. When exposed to harmine, tetrahydroharmine (THH), and harmaline—major components of ayahuasca—the neurospheres expanded in size. Additionally, the stem cells exhibited characteristics closer to fully matured neurons when exposed to these ayahuasca compounds. This suggests that some psychedelic elements within ayahuasca may encourage neurogenesis, although further human studies are needed to confirm this effect.

The Potential Benefits of Psychedelics and Neurogenesis

Research in this area is relatively new and revolves around a complex process that remains incompletely understood. While it's challenging to draw definitive conclusions regarding the connection between psychedelics and neurogenesis, existing evidence suggests a potential link. Psychedelics may enhance neurogenesis in specific brain areas, which could influence learning, memory, and depression. Regardless of the precise role neurogenesis plays in the positive effects of psychedelics, the techniques employed at Confluence Retreats have been statistically associated with increased well-being, reduced depressive symptoms, and an enhanced sense of connection to nature. If you're interested in learning more about how we integrate the latest research at Confluence Retreats to create a transformative psychedelic experience, please explore our resources further.

Oregon's Legal Psilocybin Initiative (Measure 109)

Oregon's groundbreaking Legal Psilocybin Initiative, also known as Measure 109, represents a significant milestone in psychedelic policy. This initiative legalizes supervised medical psilocybin use, paving the way for the exploration of the therapeutic potential of psychedelics in a controlled and regulated setting. By acknowledging the importance of a supportive and structured environment, Oregon is leading the charge in facilitating responsible and transformative psychedelic experiences. Measure 109 reflects an increasing recognition of the positive impact that psychedelics can have when used in a carefully controlled context, further integrating these substances into modern healthcare and personal development practices.

Note: This articles is based on a blog that originally appeared on the Synthesis Institute's website here.